a. Responsible: Dr. Alejandra Fanovich
b . Objectives
- To develop composite scaffolds (porous blocks/films) functionalized with active sustances of high biotechnological interest.
- To synthesize nanostructured biomaterials based on hydroxyapatite and other calcium phosphates by using high pressure techniques.
c . Description of ongoing projects
Functionalized composites scaffolds
This project proposes to implement an integrated process (extraction/impregnation) using supercritical CO2 to develop functionalized biomaterials. Different natural active sustances are known to act against multiresistant microorganisms, causing high interest in their isolation from natural sources. The developed process allows to extract with high efficiency the active ingredients fron natural products using CO2 in supercritical conditions. Thus, by an integrated process such extracts are used to impregnate composite biomaterials with diverse morphologies. The process requires the control of various parameters as T, P , time, process or batch recycle , etc. Thus, it is possible to obtain a porous support having antibacterial activity in an unique process. As the solvent is removed as a gas no toxic residue remains in the product, so the supercritical CO2 is called "green solvent".
2 - Porous composite bioceramics.
The goal of this project aims to synthesize nanostructured porous composites of hydroxyapatite and titanium dioxide (HA-TiO2 ) by applying high pressure techniques. Specifically, it aims to synthesize nanoparticles of HA by a hydrothermal method. Hydroxyl groups present in the hydroxyapatite structure can be condensed with the Ti alkoxide resulting an union (HA)-O-Ti. The polycondensation leads to a gel with hydroxyapatite particles anchored to the TiO2 network and homogeneously distributed in the final structure. The drying of the gels is performed with CO2 in supercritical conditions, this method prevents the collapse of the pores and maintains the porous structure (like aerogels). We study the structural, morphological, mechanical and biological properties of the obtained materials.